PDI · v1.0 · April 2026
Working in collaboration with Mayo Clinic
Patent pending · USPTO Track One

You pay for 100% of your members.
You measure 7%.

93%

of behavioral health risk is
unmeasured, unmanaged, and unpriced.

— Three compounding gaps —
GAP 1
Penetration
75%+
of members never reach validated behavioral measurement.
GAP 2
Sensitivity
~25%
of those measured are misclassified by single-test screening.
GAP 3
Routing
~67%
of positive screens never convert to care.
These gaps compound into the 93% of risk.
from the Net Structural Exposure Model · patent-derived

This is not a utilization problem. It's a measurement failure.

That gap has a measurable cost.

— The Pre-Diagnostic Index
$515 per member, annually
$43 PMPM · per member per month
Now quantify it

Two independent models.
One number.

Both models recalculate live as you enter your population. Drawn from entirely different published source sets — they share zero inputs.

Population
Members
Both models recalculate on change
1 100 1K 10K 100K 1M 10M 160M
Penetration
Population Penetration Model
Prevalence × Productivity-Medical Cost
Percent of population structurally affected
default 8.5%
%
Affected members 85,000
Annual cost per structurally affected life
default $6,480
$
Subtotal $550,800,000
Workflow friction overhead (per member)
default $3
$
Applied to pop. $3
Annual Structural Exposure
$553,800,000
Per member: $554 · PMPM: $46
Gap
Screening Gap Model
(1 − Screening Rate) × MDD × Incremental Cost
Documented depression screening rate
default 4.2%
%
Unmeasured 95.8%
MDD prevalence (adult population)
default 8.4%
%
Exposed members 80,472
Direct incremental annual healthcare cost
default $6,404
$
Cost basis 38.1% of $16,854
Annual Structural Exposure
$515,342,000
Per member: $515 · PMPM: $43
— THE STANDARD —

The Pre-Diagnostic Index

the number behind the 93%
$515
per member · annually
$43 PMPM · per member per month

Where two independent models converge — taken at the conservative bound.

— Validation · per member —
Population Penetration
$554
Screening Gap
$515
Structural · patent-derived
$593
Convergence band: $515 – $554 per member

The structural model explains why the exposure must exist. The two external models independently validate where it lands. The PDI is the conservative number you take home.

— How the gap gets closed —

Here's why that number exists.

Three gaps. Three fixes. One architecture.

The Pre-Diagnostic Index™ measures the exposure. O2OS™ is the infrastructure that closes it — one layer at a time.

GAP 1
Penetration Gap
75%+ never reached

Most members never reach validated behavioral measurement at all.

O2OS
Fix
Stress Number
across 100% of members

A standardized measurement layer deployed across the entire member population — not just the subset that reaches a clinical visit.

GAP 2
Sensitivity Gap
~25% misclassified

Single-test screening tools misclassify roughly one in four measured individuals.

O2OS
Fix
Stress Number
continuous · multi-domain

A continuous, multi-domain measurement signal that replaces point-in-time screening error with an architecturally stable index.

GAP 3
Routing Gap
~67% never convert

Most positive signals never translate into care. Identification without connection does nothing.

O2OS
Fix
Smart Referral Engine
inside O2OS infrastructure

Routing infrastructure that converts every positive Stress Number™ into a committed intervention pathway.

All three layers operate within O2OS
— One architecture. Three gaps closed. —

This is O2OS

The Pre-Diagnostic Index™ quantifies the exposure.
O2OS is the infrastructure that eliminates it.

Working in collaboration with Mayo Clinic · Utility patent application pending
— The proof beneath the standard —

Why the convergence is not a coincidence.

The patent-derived causal architecture that explains why the two external models must agree.

The Net Structural Exposure Model
Patent-derived · explains why the exposure must exist
NSR-2026-001 · Net Structural Exposure · Medical-Only Model · Per 1,000,000 Members
GAP 1
Penetration · 75%+
750,000
1,000,000 × 75%
Never reached by validated behavioral screening.
GAP 2
Sensitivity · ~25%
62,500
250,000 × 25%
Single-test screening misclassifies ~25% of measured.
GAP 3
Routing · ~67%
125,000
187,500 × ~67%
70–80% of positive screens never convert to care.
93%
of behavioral health risk outside structured infrastructure
937,500 of 1,000,000 members
Net Structural Exposure · Base Case
$593M
Sensitivity range (λ): $494M – $692M
Assumptions: C=$6,200 · πp=17.5% · λ=30%

Methodology: Exposure model derived from CMS utilization data, peer-reviewed sensitivity benchmarks, and published referral conversion studies. Published by The Oxygen Plan Corporation for institutional discussion and methodological transparency. Utility patent application pending.

— Source Citations —
CDC NCHS Data Brief No. 527 (2024) · Population prevalence of depression (NHANES 13.1%)
Greenberg et al. (PharmacoEconomics 2021) · Evans-Lacko & Knapp (2016) · AAFP Cost of Care · Direct healthcare expenditure + productivity loss
USPSTF Evidence Synthesis 223 · Akincigil & Matthews (2017) · Documented depression screening rates
NIMH · 2021 NSDUH · National MDD prevalence
Greenberg et al. (Advances in Therapy 2023) · Direct incremental annual healthcare cost · $16,854/adult MDD
— See how this applies —

Explore the PDI across 60 institutional use cases.

From commercial payers to Medicaid MCOs, from reinsurance to self-insured employers — the PDI behaves identically. Same math. Different member bases.

60 Institutional Use Cases →
— Licensing the Standard —

License the standard.

The Oxygen Plan Corporation licenses institutional use of the Pre-Diagnostic Index and its three infrastructure layers:

◆ The Pre-Diagnostic Index framework
The measurement standard, conservative bound, per-member exposure methodology.
◆ Stress Number integration
Deploy the clinically validated measurement primitive across your member population.
◆ Smart Referral Engine access
Routing logic that converts positive signals into committed intervention pathways.
A single Strategic Foundational Partner seat is being established.
License the Standard →
Qualified institutional inquiries reviewed individually.