A clinically validated measurement layer for stress, anxiety, and depression—built for healthcare, policy, and scale.

Behavioral health is overwhelmed—not because people don't care, but because systems lack clarity.
Clinicians face:
Organizations face:
Without a shared measurement language, behavioral health cannot scale responsibly.

Stress Number™ is a clinically validated metric that measures stress, anxiety, and depression risk across three life domains: Home, Work, and Social.
Unlike single-dimension tools, Stress Number™ captures context.
It delivers a 0–30 score, validated by Mayo Clinic, with a clinical threshold of ≤23 identifying elevated risk.
It is:
One number. Three domains. Clinical precision.

The Stress Number™ is a clinically validated biomarker that quantifies stress-related risk across home, work, and social life. It provides a single, standardized measurement designed to function across clinical, organizational, and population contexts.
The Stress Number™ represents the first clinically validated behavioral health biomarker — a standardized measurement that quantifies stress, anxiety, and depression risk across home, work, and social domains. Validated through peer-reviewed research and developed in collaboration with Mayo Clinic, it functions as a consistent measurement layer across clinical, employer, payer, and population health systems.
This marks a turning point: The Oxygen Plan™ is transitioning from experimental assessment tools toward infrastructure-grade measurement that supports decisions, stratification, and outcomes at scale.
| Criterion | Stress Number™ | Typical Screeners |
|---|---|---|
| Clinically validated | ✓ | △ |
| Single numeric output | ✓ | ✕ |
| Multidomain measurement (home, work, social) | ✓ | ✕ |
| Comparable across populations | ✓ | ✕ |
| Longitudinal tracking | ✓ | △ |
| Designed for systems and policy use | ✓ | ✕ |
✓ = Meets criterion △ = Partial / indirect ✕ = Does not meet criterion
Stress Number™ was developed in collaboration with Mayo Clinic and validated through peer-reviewed research conducted by Mayo Clinic research personnel.
The research demonstrated ROC AUC performance of 0.88–0.92 against established clinical instruments (PHQ-9, GAD-7, PSS-10), with a validated cutoff threshold (≤23) identifying elevated risk.
Results were published in a peer-reviewed journal—not a white paper, not a press release. This is the level of validation that health systems, payers, and regulators require before adopting a new measurement standard.
This is not a wellness estimate. It is a pre-diagnostic signal with clinical evidence CLINICAL COLLABORATION
Developed in collaboration with Mayo Clinic and validated through peer-reviewed research (2018).


The Oxygen Plan™ operates as a measurement and routing layer:
1. User completes assessment
2. Stress Number™ generated across three domains
3. Risk stratification occurs
4. Guided referrals and follow-ups enabled
5. Outcomes tracked longitudinally
The platform integrates cleanly into existing workflows—supporting clinicians without replacing them.
The Oxygen Plan™ is designed for organizations responsible for population-level behavioral health outcomes, including: Healthcare systems, Public health agencies, Employers, Payers, Community organizations.
Each stakeholder benefits from a shared measurement standard while maintaining their role and autonomy.

Precision in service of people.
Behavioral health data demands restraint.
The Oxygen Plan™ was built with governance, transparency, and ethical use at its core.
Measurement exists to support care—not to manipulate, monetize distress, or replace human judgment.
We believe infrastructure should serve people, not extract from them.

A Clearer Signal Before Crisis
Over 19 years of development. Self-funded. Mission-driven. Founded by Eric Lucas, a former Fortune 250 VP Marketing and Corporate Officer, The Oxygen Plan™ reflects over 19 years of development beginning with a 2008 patent filing and early collaboration with Mayo Clinic.
The platform has been self-funded with more than $1 million invested and deployed through enterprise and EAP channels, including sustained initial engagement with Microsoft and a government entity, where it was made available across a workforce exceeding 100,000 employees.
The Oxygen Plan™ remains founder-led, independently owned, and designed for long-term stewardship rather than rapid commercialization.
This is mission-driven infrastructure built deliberately—not a product rushed to market.

The Oxygen Plan Corporation holds a comprehensive intellectual property portfolio spanning 27 patent families across six architectural layers—from foundational measurement methodology to governance infrastructure.
The platform is built on:
This is not a feature set. It is a defensible infrastructure position.

If you are exploring better ways to measure, understand, or support behavioral health at scale, we welcome the conversation.
